Skip to main content


ESMINT is one of the project partners and is responsible for the Work Package “Dissemination, transfer, scientific data pooling and sharing”.

TENSION strives to compare the safety and effectiveness of endovascular thrombectomy as compared to best medical care alone in the treatment of acute ischemic stroke patients with extended stroke lesions defined by an Alberta Stroke Program Early CT Score (ASPECTS) score of 3-5 and in an extended time window (up to 12 hours or unknown time of symptom onset).

Up to 714 subjects will be randomized. The primary endpoint will be functional outcome assessed by the modified Rankin scale at 90 days post-stroke (“mRS shift analysis”). By this, the study aims to provide innovative treatment to patients with severe stroke to reduce the individual and societal burden of death and dependency from a stroke.

> Read the ESMINT press release about TENSION (20 July 2018)

> More information (TENSION website)

Project Partners

The TENSION study consortium consists of 15 participating organisations based in eleven different countries. It brings together renowned researchers and clinicians from across Europe, each with a strong scientific and clinical background and outstanding expertise in the field of acute stroke diagnostics and treatment.

The TENSION Consortium consists of the following partners:

  • Universitätsklinikum Hamburg-Eppendorf
  • Universitätsklinikum Heidelberg
  • Medizinische Universität Innsbruck
  • Charles University, Hradec Kralove
  • Aarhus Universitetshospital
  • CHU de Reims
  • Oslo University Hospital
  • Stockholms Lans Landsting
  • Comenius University’s Jessenius, Faculty of Medicine and University Hospital
  • Hospices Civils de Lyon
  • ECRIN – European Clinical Research Infrastructure Network
  • eppdata GmbH
  • ESMINT – European Society for Minimally Invasive Neurological Therapy
  • SAFE – Stroke Alliance for Europe
  • ICHOM – International Consortium for Health Outcomes Measurement

TENSION in the media


Bendszus M, Fiehler J, Thomalla: New Interventional Stroke Trials. Editorial Clinical Neuroradiology, March 2019, Volume 29, Issue 1, pp 1–1.

Bendszus M, Bonekamp S, Berge E, Boutitie F, Brouwer P, Gizewski E, Krajina A, Pierot L, Randall G, Simonsen CZ, Zeleňák K, Fiehler J, Thomalla G: A randomized controlled trial to test efficacy and safety of thrombectomy in stroke with extended lesion and extended time window.  Int J Stroke. 2018 Aug 29.

Press releases

20.07.2018: ESMINT (European Society of Minimally Invasive Neurological Therapy): “ESMINT partners in EU funded research project: Clinical study starts in eight European countries”.

20.07.2018: NeuroNews, “Clinical study looking into mechanical thrombectomy for major stroke starts in eight European countries”.

02.07.2018: Hamburg, Germany: “Ist die Katheterbehandlung auch bei größeren Schlaganfällen effektiv?”.

02.07.2018: Heidelberg, Germany: “Aktuelle Studie: Ist die Katheterbehandlung auch bei größeren Schlaganfällen effektiv?”.